Exercise-induced ruptured renal tumour in a young patient with hereditary leiomyomata-associated renal cell carcinoma (HLRCC): a case report

Abstract Background Hereditary leiomyomatosis-associated renal cell carcinoma (HLRCC) is rare with only 300 families reported to date worldwide. Despite highlighting malignancy, it infamous for its cutaneous and leiomyomatosis component as the more common cause of presentation. This report highlight presentation HLRCC which occurs in a teenager unfortunately complicated exercise-induced tumour rupture. Case A 22-year-old gentleman presented severe right lower abdominal pain 4 days, associated fever nausea following session strenuous exercise. He has first-degree relatives second-degree from his maternal side who were genetically tested positive HLRCC. Clinical examination revealed tender lumbar iliac fossa region. computed tomography kidneys demonstrated ruptured large subcapsular contained retroperitoneal hematoma. An emergency radical nephrectomy was performed, he recovered well. The histopathological consistent carcinoma. Conclusion Identification this underreported familial malignancy paramount onset neoplasia much earlier life. necessitates screening family members at younger age, management followed by life-long surveillance.